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Remote skin and <t>blood</t> <t>sampling</t> of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using <t>Tasso</t> <t>devices</t> from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).
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Remote skin and <t>blood</t> <t>sampling</t> of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using <t>Tasso</t> <t>devices</t> from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).
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Remote skin and <t>blood</t> <t>sampling</t> of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using <t>Tasso</t> <t>devices</t> from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).
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Remote skin and <t>blood</t> <t>sampling</t> of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using <t>Tasso</t> <t>devices</t> from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).
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Remote skin and <t>blood</t> <t>sampling</t> of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using <t>Tasso</t> <t>devices</t> from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).
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Remote skin and <t>blood</t> <t>sampling</t> of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using <t>Tasso</t> <t>devices</t> from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).
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Remote skin and <t>blood</t> <t>sampling</t> of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using <t>Tasso</t> <t>devices</t> from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).
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Remote skin and <t>blood</t> <t>sampling</t> of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using <t>Tasso</t> <t>devices</t> from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).
Blood Sampling Device, supplied by Tasso Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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blood samples  (Tasso Inc)
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Remote skin and <t>blood</t> <t>sampling</t> of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using <t>Tasso</t> <t>devices</t> from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).
Blood Samples, supplied by Tasso Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Remote skin and blood sampling of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using Tasso devices from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).

Journal: JID Innovations

Article Title: Remote Skin and Blood Sampling for Translational Connective Tissue Disorder Research: A Proof-of-Concept Pilot Study

doi: 10.1016/j.xjidi.2025.100421

Figure Lengend Snippet: Remote skin and blood sampling of connective tissue disorders captures inflammatory biomarker expression. (a) Example photos of hyperpigmentation of the forearm in a patient with systemic lupus erythematosus (left) and scars on the elbow of a patient with discoid lupus (right) who provided tape strip samples. ( b) Volcano plot of RNA expression assessed by microarray in lupus versus healthy tape strips (n = 8 lupus vs 8 healthy). ( c) Volcano plot of protein expression in serum samples obtained using Tasso devices from donors with lupus versus healthy donors (n = 5 lupus vs 3 healthy; not every patient consented to both blood and skin sampling). ( d) Volcano plot of RNA expression in morphea versus healthy tape strip samples (n = 3 morphea vs 8 healthy). ( e) Volcano plot of RNA expression in lupus versus morphea tape strips (n = 8 lupus vs 3 morphea).

Article Snippet: We sought to evaluate the feasibility of skin tape strip and Tasso blood device sampling for remote molecular profiling of connective tissue disorders, including lupus and morphea.

Techniques: Sampling, Biomarker Discovery, Expressing, Stripping Membranes, RNA Expression, Microarray